A research was done on mice which showed that the medicine which is used during the treatment of cancer, when used in neurodegenerative diseases like Alzheimer’s disease, has given very good results.
Pennsylvania State University Stanford University Report
Research by scientists at Pennsylvania State University, Stanford University and an international team of collaborators found that blocking an enzyme called indoleamine-2,3-dioxygenase 1 (IDO1) in a mouse model of AD restored metabolism in brain astrocytes, and rescued memory and brain function.
The findings suggest that IDO1 inhibitors currently being developed as treatments for a variety of cancers — including melanoma, leukemia, and breast cancer — could be repurposed to treat the early stages of AD and potentially other neurodegenerative diseases, which would be the first time these inhibitors have been used as treatment for chronic conditions.
Stanford University School of Medicine
Inhibiting this enzyme, particularly with compounds that have previously been tested in human clinical trials for cancer, could be a major step in finding ways to protect our brain from damage caused by aging and neurodegeneration. “We are showing that there is high potential for IDO1 inhibitors, which are already in the repertoire of drugs being developed for cancer treatment,” said Katrin Andreasson, MD, the Edward F. and Irene Pimley Professor of Neurology and Neurological Sciences at Stanford University School of Medicine.
Melanie McReynolds, the Dorothy Foehr Hauck and J. Lloyd Hauck Early Career Chair in Biochemistry and Molecular Biology at Penn State, to target and treat Alzheimer’s.
“In the broader context of aging, neurological decline is one of the biggest co-factors of being unable to have healthy aging,” said PhD. The benefits of understanding and treating metabolic decline in neurological disorders will affect not only those who have been diagnosed, but our families, our society, our entire economy.
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